Mechanisms of antimalarial activity and drug resistance : Indian antimalarial medicinal plants

Asian Journal of Pharmaceutical and Health Sciences,2023,13,3,2872-2877.
Published:December 2023
Type:Research Article
Author(s) affiliations:

Shilpa Valiyaparambil1, Muddukrishnaiah Kotakonda1*, Selvaraj Palanisamy, Natarajan Ashokkumar2, Rameswari Shanmugam3, Poornima Marimuthu4, Samuel Thavamani B5, Sirajudheen Mukriyan Kallungal1

1Department of Pharmaceutics, Jamia Salafiya Pharmacy College, Pulikkal, Malapuram District, Kerala, India.

2Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002. Tamil Nadu, India.

3Department of Pharmaceutical Chemistry, Sree Sastha Pharmacy College, Chembarambakkam, Tamil Nadu, India.

4Department of Pharmaceutics, Tagore College of Pharmacy, Rathinamangalam, Melakotayur, Chennai, Tamil Nadu, India.

5Department of Pharmacognosy, Ahalia School of Pharmacy, Kozhippara, Pudussery East, Palakkad, Kerala, India.


Malaria is generally controlled through pharmacological therapy and is preventable to a certain extent. Most antimalarial drugs that have been in use for decades are now limited owing to the emergence and spread of drug resistance. Mechanisms of antimalarial activity and drug resistance: Indian antimalarial medicinal plants. A thorough search for antimalarial drugs was conducted in several databases, including Scopus, Embase, Cochrane, and PubMed. The keywords used for the search were antimalarial drugs, mechanisms of action, antimalarial resistance, and Indian medicinal plants. This study included all publications in English. Studying the method of action of drugs and the mechanism of drug susceptibility is critical for optimizing their benefits and developing novel therapies with new targets. Little is known about the function of antimalarial medications and development of resistance. Many chemicals used for antimalarial activity have developed resistance. The demand for new antimalarial medicines has prompted significant efforts to develop novel antimalarial drugs from plants. Information from different Indian tribal communities and research publications was collected and compiled. The mechanisms of action, drug resistance, and antimalarial agents of Indian medicinal herbs have been documented in this study. This would aid future research on the antimalarial activity in plants.

Elimination of drug molecules by efflux pump