Gomphrena globosa is commonly known as Globe Amaranth, is one of the traditional medicinal plant widely distributed in North America, Bangladesh and India. Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence considered as a priceless lane of new bioactive molecules. Gomphrena species found all over the world and has been recognized in different traditional system of medicines for the treatment of various diseases of human being. Globe Amaranth is easily found in the gardens as an ornamental plant. It was empirically proven that medicinal plants have the ability to cure certain diseases such as dysentery. All parts of the plant can be used as medicine. It is used in folk medicines for the treatment of different ailments. It is used in the treatment of high blood pressure and used for oliguria, heat and empacho. It is a popular edible plant and used as food colorant. The present review is to focus on the pharmacological activities and potential of phytochemicals of the plant Gomphrena globosa .It comprises approximately 120 species. Phytoconstituents present in it are flavanoids, phytosterols, phenolics, Betacyanins and terpinoids. Plant parts are mainly used to treat body sore, malaria, Bacterial infections and Jaundice, urinary problem, high cholesterol, cough, fever, diarrhea, liver disorders, kidney disorders and cooling. Further work is recommended to isolate and characterize the bioactive compounds which are responsible for the activities in the plant.