Drug induced liver injury is a common cause of acute liver failure. Beta blockers are a widely prescribed class of drugs; however, hepatotoxicity is a rare adverse effect. Here we report a case of 54 years old female patient with Metoprolol induced hyperbilirubinemia and transaminitis. Drug induced liver injury (DILI) is an important differential diagnosis in many patients in clinical hepatology. DILI is the leading cause of acute liver failure and is an important safety issue when new drugs are developed.