Asian Journal of Pharmaceutical and Health Sciences,2022,12,1,2629-2635.
Flavonoids are one of the most important phytochemicals in terms of its significant pharmacological activity. Quercetin is one of the most abundant dietary flavonoids with poor aqueous solubility and poor oral absorption. It is rapidly cleared from the body following oral administration. Development of lipid-drug complex is a potential approach for improving the therapeutic efficacy of Quercetin. The present study aimed to formulate Quercetin Pharmacosomes and Biotin-Chitosan conjugated Quercetin Pharmacosomes for tumour targeted delivery. The Characterisation and In vitro drug release studies indicate that the prepared Phospholipid complexes are promising candidates for further studies in the delivery of Quercetin and other herbal drugs.
for 24 hours in the dissolution medium of pH 7.4 phosphate buf fer and pH 5 acetate buf fer solutions (900 ml). At predetermined time intervals, samples were withdrawn and was replaced with fresh buf fer solution. The absorbance of the sample was measured at 256 and 254 nm respectively . The cumulative release of the sample was calculated by using suitable equations with the help of the standard curve. Drug release kinetics was studied by the kinetic equations such as zero order , first order , Higuchi model, KorsmeyerPeppas model etc. INTESTINAL PERMEA TION STUDY  Chicken ileum was kept in phosphate buf fer for 20 min to equilibrate. The The Franz Dif fusion cell receptor compartment was comprised of 20 ml of pH 7.4 phosphate buf fer . The temperature of the receptor compartment was maintained at 36℃±0.5℃ under magnetic stirrer at 100 rpm. After 20 minutes, 150 mg Quercetin w