Patient had a history of Pemphigus Vulgaris for past 3 years and was now admitted due to the sudden extensive flare up. The subject complained painful erosions covering more than 40% of the body surface area. Lesions started orally and were short lived and formed peripheral extensive erosions. Periorbital and Perioral lesions were present . Patient was immediately initiated on Corticosteroids and antibiotics. Protein supplementation, Condy’s Compression along with other local applicants were prescribed. A partial pulse with Dexamethasone was given for two days. The overwhelming number of medications that created confusions of administration for the care taker were resolved through elaborate patient counseling . Apart from adverse drug reactions monitoring which forms a part of clinical pharmacist responsibilities, this case shows the inevitability of clinical pharmacist in educating patients and their care takers in both medication management and need for the compliance.