A case on myocardial infarction (MI) is described. The subject complained of chest pain for two days aggravating 4 hours before admission to the emergency room. On evaluation the patient was diagnosed with anterolateral MI. Initial pharmacotherapy included aspirin, clopidogrel, atorvastatin, nicorandil, Inj heparin. Emergency cardiac catheterization and primary PTCA was performed. The drug therapy included aspirin, clopidogrel, rosuvastatin, carvedilol, pantoprazole, sorbitrate, injection heparin, tirofiban, ramipril, ivabradine, syrup KCl, torsemide, spironolactone, ranolazine, clonazepam. This case is a clear evidence of irrational prescription that includes polypharmacy, drug interaction and medication error. The prescription clearly depicts need of a clinical pharmacist intervention in overall therapy of the patient.