Retinitis pigmentosa is a group of genetic disorder that affects the retina's ability to respond to light. This inherited disease causes a slow loss of vision, beginning with decreased night vision and loss of peripheral vision resulting in tubular vision. Eventually, blindness results in the affected individual. Regrettably, there is no cure for retinitis pigmentosa till date. Here, we are presenting a case of a 75 years old male who was diagnosed as a case of retinitis pigmentosa when he was 50 years old. He was also suffering from diabetes and asthma. Two units of umbilical cord whole blood were transfused to the patient within an interval of one month. Outstanding improvement was observed in the visual field of the patient along with improvement in diabetes and asthma.