Clear Cell Carcinoma of Ovary, Uterine Corpus and Cervix-Synchronous or Metastatic?

Asian Journal of Pharmaceutical and Health Sciences,2015,5,3,1317-1319.
Published:August 2015
Type:Case Report
Author(s) affiliations:

Tushar Kar, Asaranti Kar*, Jagannath Mishra, Lity Mohanty, Shilpa Anupurba

O & G Department, S.C.B. Medical College, Cuttack, India.


Clear cell carcinoma is a rare type of ovarian epithelial malignancy accounting for less than 5% of all ovarian epithelial cancers. It is characterized by appearance of special type of cells with abundant clear cytoplasm and centrally placed nuclei arranged in solid or tubulo-cystic/glandular pattern with presence of hobnail cells frequently. Due to bad prognosis, it is considered as a high grade tumor. Ovarian clear cell carcinoma spreading to uterus and cervix is a very rare presentation. In such instances it becomes difficult to distinguish a metastatic lesion to uterus and cervix from ovarian primary from synchronous or simultaneous appearance of multiple cancers. We present such a case of ovarian clear cell carcinoma with concurrent involvement of uterus and cervix in a 60-year-old multiparus female. Simultaneously, we have tried to solve the conflict of metastatic and synchronous lesions in ovary and uterus.

Enlarged multinodular ovarian tumor with uterus showing thickened endometrium