Effect of Nutrients and Culture Conditions on Antibiotic Synthesis in Streptomycetes

Asian Journal of Pharmaceutical and Health Sciences,2013,3,3,810-815.
Published:August 2013
Type:Review Articles
Author(s) affiliations:

Razieh Rafieenia

Department of Chemical Engineering and Biotechnology, Islamic Azad University of Iran, Science and research Branch, Tehran, Iran.


Antibiotics are important secondary metabolites that produced through complex biosynthetic pathways by some microorganisms in specific conditions. They have been the best option for many infectious diseases in the past decades. Diversity of antibiotic groups makes them to be effective for a wide range of microbial infections. These valuable compounds are produced mostly by genus Streptomyces in specific conditions. Optimization of medium composition and fermentation process are of vital importance in pharmaceutical industries for increasing antibiotic production in large scale and minimization of operating costs. This review aims to communicate about different factors affecting on antibiotic synthesis in streptomycetes.

Best carbon sources for antibiotic production by different microorganisms