Asthma is a major public health concern and one of the most common chronic disease worldwide. 50 asthmatic patients qualifying for third step in asthma treatment were enrolled for study. After assessing the lung function they were divided into two groups. One group was prescribed inhaled salmeterol (50mcg bid) and inhaled fluticasone (100mcg BID) and the other group was prescribed inhaled formoterol (6mcg BID) and inhaled budesonide (200mcgBID) for four weeks duration. Spirometric evaluation was done in both the groups to see the improvement in lung functions. Both the groups were compared.