Synthesis and Biological Screening of N-Substituted Derivatives of N-benzyl-4-chlorobenzenesulfonamide

Asian Journal of Pharmaceutical and Health Sciences,2012,2,3,384-389.
Published:August 2012
Type:Research Article
Author(s) affiliations:

Aziz-ur-Rehman1*, Awais-ur-Rehman2, Muhammad Athar Abbasi1, Hira Khalid1, Parsa Dar1, Khalid Mohammad Khan3

1Department of Chemistry, Government College University, Lahore-54000, Pakistan.

2Department of Chemistry, Minhaj University, Lahore, Pakistan.

3HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.


In the present study, a series of N-substituted derivatives of Nbenzyl-4-chlorobenzenesulfonamide has been synthesized. The reaction of benzylamine (1) with 4-chlorobenzenesulfonyl chloride (2) yielded the parent compound N-benzyl-4- chlorobenzenesulfonamide (3), which further on treatment with different electrophiles (4a-i) in the presence of sodium hydride furnished into N-substituted sulfonamides (5a-i). The structure 1 of synthesized compounds has been established by IR, H-NMR and EI-MS. All the compounds have been screened for their antimicrobial activity.

Synthesis of N-substituted sulfonamides derived from benzylamine